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SCI Article

C-H Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products
Author
Youn, So Won (Dept Chem); Youn, So Won (Res Inst Nat Sci);
Corresponding Author Info
Chen, DYK (reprint author), Seoul Natl Univ, Dept Chem, Seoul 151742, South Korea.
E-mail
Document Type
Review
Source
CHEMISTRY-A EUROPEAN JOURNAL Volume:18 Issue:31 Pages:9452-9474 Published:2012
Times Cited
166
External Information
http://dx.doi.org/10.1002/chem.201201329
Abstract
The recent advent of transition-metal mediated C?H activation is revolutionizing the synthetic field and gradually infusing a C?H activation mind-set in both students and practitioners of organic synthesis. As a powerful testament of this emerging synthetic tool, applications of C?H activation in the context of total synthesis of complex natural products are beginning to blossom. Herein, recently completed total syntheses showcasing creative and ingenious incorporation of C?H activation as a strategic manoeuver are compared with their non-C?H activation counterparts, illuminating a new paradigm in strategic synthetic design.
Web of Science Categories
Chemistry, Multidisciplinary
Funding
National Research Foundation of Korea (NRF) [2010-0017149, 2010-0007737]; Ministry of Education, Science and Technology (MEST)
Language
English
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