바로가기 메뉴

  >   연구성과   >

Recent Articles

  • 한양대학교 기관으로 출판된 최신 SCI급 논문현황 (Web Of Science에서 제공되는 자료)
  • 매주 1회 업데이트

SCI Article

Allele-Specific Phenotype Suggests a Possible Stimulatory Activity of RCAN-1 on Calcineurin in Caeno
Author
Li, Weixun (Dept Life Sci); Choi, Tae-Woo (Dept Life Sci); Ahnn, Joohong (Dept Life Sci); Lee, Sun-Kyung (Dept Life Sci); Li, Weixun (PLUS Life Sci BDR Team BK21); Choi, Tae-Woo (PLUS Life Sci BDR Team BK21); Ahnn, Joohong (PLUS Life Sci BDR Team BK21);
Corresponding Author Info
Ahnn, J; Lee, SK (reprint author), Hanyang Univ, Dept Life Sci, Seoul 04763, South Korea.; Ahnn, J; Lee, SK (reprint author), Hanyang Univ, PLUS Life Sci BDR Team BK21, Seoul 04763, South Korea.; Ahnn, J; Lee, SK (reprint author), Hanyang Univ, Res Inst N
E-mail
joohong@hanyang.ac.kr sunkyungl@hanyang.ac.kr
Document Type
Article
Source
MOLECULES AND CELLS Volume:39 Issue:11 Pages:827-833 Published:2016
Times Cited
0
External Information
http://dx.doi.org/10.14348/molcells.2016.0222
Abstract
Regulator of calcineurin 1 (RCAN1) binds to calcineurin through the PxIxIT motif, which is evolutionarily conserved. SP repeat phosphorylation in RCAN1 is required for its complete function. The specific interaction between RCAN1 and calcineurin is critical for calcium/calmodulin-dependent regulation of calcineurin serine/threonine phosphatase activity. In this study, we investigated two available deletion rcan-1 mutants in Caenorhabditis elegans, which proceed differently for transcription and translation. We found that rcan-1 may be required for calcineurin activity and possess calcineurin-independent function in body growth and egg-laying behavior. In the genetic background of enhanced calcineurin activity, the rcan-1 mutant expressing a truncated RCAN-1 which retains the calcineurin-binding PxIxIT motif but misses SP repeats stimulated growth, while rcan-1 lack mutant resulted in hyperactive egg-laying suppression. These data suggest rcan-1 has unknown functions independent of calcineurin, and may be a stimulatory calcineurin regulator under certain circumstances.
Web of Science Categories
Biochemistry & Molecular Biology; Cell Biology
Funding
National Research Foundation of Korea (NRF) - Korean Ministry of Science, ICT & Future Planning [2015R1D1A1A 01059062, 2015R1D1A1A01058179]
Language
English