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SCI-E Article

Mammographic Breast Density, Benign Breast Disease, and Subsequent Breast Cancer Risk in 3.9 Million Korean Women
성명 박보영()
소속 의과대학 예방의학교실
캠퍼스
우수선정주 2022년 09월 4째주
Author Kim, Soyeoun (Dept Hlth Sci); Tran, Thi Xuan Mai (Dept Prevent Med); 박보영 (Dept Prevent Med) corresponding author; Song, Huiyeon (Dept Epidemiol & Biostat);
Corresponding Author Info Park, B(해당 저자), Hanyang Univ, Coll Med, Dept Prevent Med, 222 Wangsimni Ro, Seoul 04763, South Korea.
E-mail 이메일 아이콘hayejine@hanyang.ac.kr
Document Type Article
Source RADIOLOGY Volume:304 Issue:3 Pages:534-541 Published:2022
Times Cited
External Information http://dx.doi.org/10.1148/radiol.212727
Abstract Background: Mammographic breast density and benign breast disease are strong risk factors for breast cancer. Accordingly, women with both risk factors may have a markedly high risk for developing breast cancer. Purpose: To investigate the risk of breast cancer associated with the combination of mammographic density and benign breast disease in Korean women, where population-based mammographic breast cancer screening is provided for all women aged at least 40 years. Materials and Methods: This is a retrospective analysis of data from a nationwide breast cancer screening program linked with the national cancer registry. The study included Korean women between 40-74 years of age screened for breast cancer between January 2009 and December 2010 and observed up to December 2020 (median follow-up of 10.6 years). Benign breast disease and breast density were extracted from mammography screening results. Cox proportional hazard regression analysis was used to calculate adjusted hazard ratios (HRs) for breast cancer risk. Results: In this study, 3 911 348 women (mean age, 53 years +/- 9 [SD]) were analyzed. During follow-up (median, 10.6 years), 58 321 women developed breast cancer. At screening, 10 729 (18.4%) cases of benign breast disease were detected among women who developed breast cancer. Women with extremely dense breasts (Breast Imaging Reporting and Data System [BI-RADS] density category D) and benign breast disease had a greater risk of breast cancer when compared with women presenting with fatty breast (BI-RADS density category A) and those without benign breast disease (HR, 2.75; 95% CI: 2.63, 2.88; P
Web of Science Categories Radiology, Nuclear Medicine & Medical Imaging
Funding National Research Foundation of Korea - Korean government (MSIT) [2021R1A2C1011958]
Language English
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