메인메뉴바로가기

한양대학교 산학협력단

홈으로 바로가기 > 연구정보 > 연구성과 > 금주의 우수논문

연구성과 > 금주의 우수논문

페이스북 로그인트위터 로그인카카오톡 로그인메일 전송
view

SCI-E Article

Korean Red Ginseng exhibits no significant adverse effect on disease activity in patients with rheum
성명 성윤경()
소속 의과대학 내과학교실
캠퍼스
우수선정주 2018년 04월 4째주
Author eumatol); Jun, Jae-Bum (Dept Rheumatol); 성윤경 (Dept Rheumatol) corresponding author;
Corresponding Author Info Sung, YK (reprint author), Hanyang Univ, Hosp Rheumat Dis, Dept Rheumatol, Seoul 133792, South Korea.
E-mail 이메일 아이콘sungyk@hanyang.ac.kr
Document Type Article
Source JOURNAL OF GINSENG RESEARCH Volume:42 Issue:2 Pages:144-148 Published:2018
Times Cited 0
External Information http://dx.doi.org/10.1016/j.jgr.2017.01.006
Abstract Background: Panax ginseng is a well-known immune modulator, and there is concern that its immune-enhancing effects may negatively affect patients with rheumatoid arthritis (RA) by worsening symptoms or increasing the risk of adverse effects from other drugs. In this randomized, crossover clinical trial, we evaluated the impact of Korean Red Ginseng (KRG) on disease activity and safety in RA patients. Methods: A total of 80 female RA patients were randomly assigned to either the KRG (2 g/d, n = 40) treatment or placebo (n = 40) groups for 8 wk, followed by crossover to the other treatment group for an additional 8 wk. The primary outcome was the disease flare rate, defined as worsening disease activity according to the disease activity score 28 joints-erythrocyte sedimentation rate (DAS28-ESR). The secondary outcomes were development of adverse events (AEs) and patient reported outcomes. Outcomes were evaluated at baseline and 8 wk and 16 wk. The outcomes were compared using the Chi-square test. Results: Of the 80 patients, 70 completed the full study. Their mean age was 51.9 yr, and most exhibited low disease activity (mean DAS28-ESR 3.5 +/- 1.0) at enrollment. After intervention, the flare rate was 3.7% in each group. During KRG treatment, 10 AEs were reported, while five AEs were developed with placebo; however, this difference was not statistically significant (p = 0.16). Gastrointestinal-and nervous system-related symptoms were frequent in the KRG group. Conclusion: KRG is not significantly associated with either disease flare rate or the rate of AE development in RA patients. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
Web of Science Categories Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine
Funding Korean Society of Ginseng
Language English
페이스북 로그인트위터 로그인카카오톡 로그인메일 전송 리스트