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SCI Article

Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans
Author Lee, Chang Hwa (Coll Med); Kim, Sang-Heon (Coll Med);
Corresponding Author Info Kim, SH (reprint author), Hanyang Univ, Coll Med, Dept Internal Med, 17 Haengdang Dong, Seoul 133792, South Korea.
E-mail 씠硫붿씪 븘씠肄
Document Type Article
Source PHARMACOGENETICS AND GENOMICS Volume:21 Issue:5 Pages:303-307 Published:2011
Times Cited 54
External Information PDF 븘씠肄http://dx.doi.org/10.1097/FPC.0b013e32834282b8
Abstract Recent investigations suggest genetic susceptibility of allopurinol-induced severe cutaneous adverse reactions (SCARs). However, the strength of association was variable according to phenotypes and ethnic backgrounds. To explore genetic markers for allopurinol-induced SCARs in Koreans, we genotyped human leukocyte antigen (HLA) class I alleles of 25 cases of allopurinol-induced SCARs (20 cases of drug-induced hypersensitivity syndrome and five cases of Stevens-Johnson syndrome/toxic epidermal necrolysis) and 57 patients tolerant to allopurinol. Frequencies of B*5801 [92.0 vs. 10.5%, P(c) = 2.45 x 10(-11), odds ratio (OR) = 97.8], Cw*0302 (92.0 vs. 12.3%, P(c) = 9.39 x 10(-11), OR = 82.1), and A*3303 (88.0 vs. 26.3%, P(c) = 3.31 x 10(-6), OR = 20.5) were significantly higher in SCARs compared with tolerant controls. In contrast, A*0201 was not found in SCARs patients despite relatively high frequency in tolerant controls (29.8%). We found strong positive association of HLA-B*5801 and negative association of HLA-A*0201 with the development of allopurinol-induced SCARs in the Korean population. Pharmacogenetics and Genomics 21:303-307 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Web of Science Categories Biotechnology & Applied Microbiology; Genetics & Heredity; Pharmacology & Pharmacy
Funding Ministry of Health Welfare, Korea [03-PJ10-PG13-GD01-0002]
Language English
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