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SCI Article

Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans
Author Kim, Sang-Heon (Coll Med);
Corresponding Author Info Chang, YS (reprint author), Seoul Natl Univ, Bundang Hosp, Div Allergy & Clin Immunol, Dept Internal Med, 300 Gumi Dong, Songnam, South Korea.
E-mail 씠硫붿씪 븘씠肄
Document Type Article
Source EPILEPSY RESEARCH Volume:97 Issue:20150102 Pages:190-197 Published:2011
Times Cited 57
External Information PDF 븘씠肄http://dx.doi.org/10.1016/j.eplepsyres.2011.08.010
Abstract Background: Although the US FDA recommends screening for HLA-B*1502 allele in most of Asian ancestry before initiating carbamazepine therapy, the HLA associations with carbamazepine hypersensitivity in non-Chinese Asian populations remain unclear. This study investigated the association between the HLA class I genotype and carbamazepine-induced severe cutaneous adverse reaction (SCAR) in Koreans. Methods: Twenty-four patients who had developed carbamazepine-induced SCAR (7 Stevens-Johnson syndrome (SJS), 17 drug hypersensitivity syndrome (HSS)), 50 carbamazepine-tolerant controls from the Korean Pharmacogenetic Adverse Drug Reaction Research Network and data of 485 Korean general population from a previously published study were recruited. HLA-A, -B, and -C genotyping was performed by direct DNA sequence analysis. Results: Only one of the seven SJS patients was positive for the B*1502 allele, but the frequency of B*1511 was much higher in the patients with CBZ-SJS than in the CBZ-tolerant control patients (P = 0.011, P(c) = not significant; OR = 18.0(2.3-141.2)). The frequencies of A*3101 in carbamazepine-induced HSS and SCAR were significantly higher than those in carbamazepine-tolerant controls (P(c) = 0.011, OR = 8.8(2.5-30.7) and P(c) = 0.013, OR = 7.3(2.3-22.5), respectively). The frequencies of B*1511 in carbamazepine-SJS and A*3101 in carbamazepine-HSS/SCAR were significantly higher than those in the general population. Conclusions: HLA-B*1502 does not seem to be an effective predictive marker for carbamazepine-induced SCAR, while HLA-B*1511 and A*3101 was associated with carbamazepine-induced SJS and HSS/SCAR respectively in the Korean population. (C) 2011 Elsevier B.V. All rights reserved.
Web of Science Categories Clinical Neurology
Funding Ministry of Health and Welfare, R.O.K. [A111218-11-PG01]
Language English
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