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  • 한양대학교 기관으로 출판된 최신 SCI급 논문현황 (Web Of Science에서 제공되는 자료)
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SCI Article

Pathologic Impact of Insulin Resistance and Sensitivity on the Severity of Liver Histopathology in P
Author Park, Byung Han (Dept Pediat); Yoon, Jung Min (Dept Pediat); Kim, Ja Hye (Dept Pediat); 문진화 (Dept Pediat); 이영호 (Dept Pediat); 김용주 (Dept Pediat);
Corresponding Author Info Kim, YJ (reprint author), Hanyang Univ, Coll Med, Dept Pediat, 222 Wangsimni Ro, Seoul 04763, South Korea.
E-mail 씠硫붿씪 븘씠肄kyjoo@hanyang.ac.kr
Document Type Article
Source YONSEI MEDICAL JOURNAL Volume:58 Issue:4 Pages:756-762 Published:2017
Times Cited 0
External Information PDF 븘씠肄http://dx.doi.org/10.3349/ymj.2017.58.4.756
Abstract Purpose: Insulin resistance (IR) has an important role in the development of non-alcoholic steatohepatitis (NASH). We aimed to analyze the association between liver histopathology and IR in pediatric patients with NASH. Materials and Methods: In 24 children with non-alcoholic fatty liver disease (NAFLD), we investigated whether the hepatic pathologic characteristics have relations with following three biochemical indices; IR index including homeostasis model assessment of IR (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and insulin sensitivity indices-free fatty acid (ISI-FFA). Results: Among 24 patients, 16 (66.6%) had a high NAFLD activity score (NAS), which is diagnostic of NASH. Higher serum triglyceride level was significantly correlated with a high NAS. Higher steatosis grades were significantly associated with low insulin sensitivity (p=0.023). In addition, severe lobular inflammation was associated with higher IR: HOMA-IR (p= 0.014) and QUICKI (p= 0.023). Severe fibrosis correlated with low insulin sensitivity and high IR indexes: ISI-FFA (p= 0.049), HOMA-IR (p= 0.028), and QUICKI (p= 0.007). Conclusion: Patients with high IR had more severe lobular inflammation and hepatic fibrosis. Analyses of biochemical and endocrine parameters can be applied to determine the severity of the hepatic pathologic status in patients with NASH, especially in children who cannot undergo a liver biopsy.
Web of Science Categories Medicine, General & Internal
Funding
Language English
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